Flow Chemistry; a Well-Established Technique Use to Manufacturing Large Quantities of a Given Material



Flow chemistry, also known as continuous flow chemistry or plug flow chemistry, is the process of performing chemical reactions in a tube or pipe. The process uses a pump to initiate the movement of fluid into a tube. Flow chemistry enables efficient, cheaper, safer, and cleaner chemical processes. Moreover, it helps enhance safety and reaction time and also offer multi-step synthesis. It is a highly efficient, well-established, and economic technique used for large-scale operations, such as the manufacture of large quantities of a given substance.

Thus, it is widely adopted across various end-user industries such as chemicals, petrochemicals, and pharmaceuticals. Flow chemistry offers variety of applications, including pre-treating grain and plant material for fertilizers, as well as the separation of solids from the liquid during the mining and milling process. Moreover, it can be used for batch control, lagoon drag, separation of solids from bulk materials, and much more. The pharmaceutical industry is highly dependent on the continuous flow process using a wide variety of reactors.

It is considered both the most accurate and beneficial technology for drug discovery. Therefore, there is an increasing demand for flow chemistry in the pharmaceutical industry. This method has been used during past two decades mainly in the pharmaceutical industry. Another reason this technology is becoming so popular is that it is easy to use, requiring minimal manual labor in processing areas where efficiency is important. In February 2019, Kaneka awarded by the society of synthetic organic chemistry, japan for the innovative process development utilizing continuous flow chemistry.

Flow chemistry with automation enables the quick variation of reaction conditions on a very small scale. Parameters such as temperature, reaction time, ratio of reagents, concentration, and reagents themselves can all be rapidly varied. Flow chemistry is the development and study of chemical reactions whereby reactants are combined by pumping fluids, including solutions of reagents, through tubes at known rates.

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